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Programs that provide assistance and support for individuals who exhibit pharmacological and other indicators of a drug use disorder (including those related to prescription medication), during the withdrawal period.

Programs operated by hospitals or other inpatient facilities and staffed by trained medical personnel that provide assistance and support, including medication, to help individuals who are physically dependent on one or a combination of substances during the withdrawal period. Inpatient detoxification is required when the withdrawal process is potentially dangerous or when the individual has acute medical problems.

Programs that specialize in providing detoxification services for people who have a physical dependency on an opioid substance (usually heroin, oxycodone or morphine). Detoxification methods vary but often entail stabilization via prescription medication such as methadone, buprenorphine (Subutex), buprenorphine-naloxone (Suboxone) or naltrexone administered by medical professionals. Specialized opioid detoxification programs can be either inpatient or outpatient.

Programs operated under the supervision of trained physicians, nurses or counselors on an outpatient basis in a medical clinic or other similar setting that provide assistance and support including medical treatment and possibly prescription medication to help individuals who exhibit pharmacological and other indicators of a drug use disorder involving substances other than opiates (e.g., cocaine, amphetamines, benzodiazepines) during the withdrawal period.